Melanocortin peptides such as PT-141 (bremelanotide, Vyleesi) and Melanotan II: approvals, trial results, side effects and regulator warnings.
Vyleesi · Bremelanotide · PT 141
Melanocortin receptor agonist (cyclic heptapeptide)
A melanocortin peptide approved in 2019 as Vyleesi, an as-needed injection for low sexual desire in premenopausal women. Nausea affects about 40% of users.
Read moreMelanotan II · MT-II · MT2 · Tanning injection · Barbie drug
Synthetic cyclic alpha-MSH analog (melanocortin receptor agonist)
A synthetic tanning and libido peptide created at the University of Arizona. Never approved anywhere; regulators warn against it after reports of melanoma and changing moles.
Read moreKP-10 · Kp-10 · Kisspeptin 112-121 · Metastin 45-54
Kisspeptin receptor agonist peptide
A 10-amino-acid fragment of the hormone kisspeptin that triggers LH and testosterone release in short human studies. Not approved anywhere; flagged by FDA for compounding.
Read moreMenopur · Repronex · Pergonal · Human menopausal gonadotropin · Menotropins · Menotrophin · HP-hMG · Highly purified menotropin
Urinary gonadotropin (FSH and LH activity)
Urinary FSH plus LH activity used to grow multiple eggs in IVF. Trials find it about as effective as recombinant FSH. Used with hCG in men to start sperm production.
Read moreNovarel · Pregnyl · Ovidrel · Human chorionic gonadotropin · Chorionic gonadotropin · HCG · Choriogonadotropin alfa · r-hCG
Gonadotropin (glycoprotein hormone with LH-like activity); urinary-derived or recombinant
A pregnancy hormone that acts like LH. Prescribed for male hypogonadism, ovulation induction and to protect fertility on testosterone. It does not help weight loss.
Read morePitocin · Pitocin · Syntocinon · Oxytocin nasal spray · OT · OXT
Posterior pituitary hormone (nonapeptide); oxytocic
A 9-amino-acid hormone approved as Pitocin to start or strengthen labor and control bleeding after birth. Nasal spray studies for autism and social behavior have largely failed to hold up.
Read moreScenesse · Afamelanotide · Melanotan I · MT-1 · MT-I · [Nle4, D-Phe7]-alpha-MSH · NDP-MSH · CUV1647
Melanocortin 1 receptor agonist (linear alpha-MSH analog)
A synthetic alpha-MSH analog approved as Scenesse, an implant for the rare light-sensitivity disorder EPP. Unregulated 'Melanotan 1' tanning products are a different matter.
Read moreFactrel (discontinued for human use) · Lutrepulse (discontinued) · GnRH · LHRH · Gonadotropin-releasing hormone · Gonadorelin acetate · Gonadorelin hydrochloride · Luliberin
Synthetic gonadotropin-releasing hormone (10-amino-acid peptide)
Synthetic GnRH, once sold in the US as a pituitary test and pump therapy. Now compounded for men on TRT, a use with almost no clinical trial evidence.
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Best peptides for sexual health, by evidence: bremelanotide (PT-141) is approved for low desire in women, kisspeptin is early research, melanotan II is risky.
Melanotan 1 vs Melanotan 2 compared: structure, tanning and sexual effects, the approved afamelanotide implant, melanoma and mole risks, and legal status.
PT-141 vs Viagra and Cialis: brain-acting desire drug vs blood-flow ED pills. Approvals, men's trial data, timing, side effects and who each is for.
Peptides for testosterone compared: approved hCG, compounded gonadorelin and experimental kisspeptin vs TRT. What raises levels, what protects fertility, risks.
Kisspeptin dosage in human studies: the kisspeptin-10 and kisspeptin-54 doses tested in men and women by IV, injection, pump and nasal spray. No approved dose.
Peptides for male fertility: hCG restores sperm in most men with pituitary-related low testosterone, but kisspeptin and gonadorelin shots remain unproven.
Peptides for fertility explained: approved hCG, hMG, FSH and GnRH drugs used in IVF and ovulation induction, plus where kisspeptin and gonadorelin stand.
Melanotan 2 results from studies and case reports: tanning in 2 of 3 men, darkening moles within days, melanoma cases, and other harms doctors have reported.
Melanotan 2 dosage facts: the only studies gave 0.01 to 0.03 mg/kg to a few men. There is no approved or tested tanning dose, and case reports show harm.
Melanotan 1 side effects from the Scenesse label: implant reactions, nausea, headache, darker moles and allergic reactions, plus the risks of unregulated vials.
Melanotan 1 results from human trials: how much skin darkened, how long the tan lasted, what Scenesse did for EPP and vitiligo, and what photos miss.
Kisspeptin for women: what human studies found for IVF, missed periods, PCOS and low sexual desire, why cycle timing matters, and why it is not approved.
Peptides for prostate health: proven peptide drugs treat prostate cancer, but no peptide is approved for enlarged prostate or general 'prostate support.'
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