Quick answer: there is no approved NAD+ dosage. In human studies, IV NAD+ was given at 10 mg to 750 mg per session, a registered injection trial uses 100 mg, and the oral precursors NMN and NR were taken at 250 mg to 2,000 mg a day.[1][3][5][13] None of these doses has been shown to improve energy or aging, and a clinician should set any dose.[6]
This guide lays out the amounts used in each type of study, how often they were given, and what to ask before starting. For background, see our NAD+ profile and the NAD+ topic hub.
NAD+ dosage chart: amounts used in human studies
These are research amounts, not recommendations.
| Form | Amount | Schedule | Study |
|---|---|---|---|
| IV drip | 750 mg | Once, over 6 hours | 8 healthy men[1] |
| IV drip | 500 mg | Daily for 4 days | Wellness-clinic review[2] |
| IV | 10 mg | Daily for 7 days | 180 people with heart failure[3] |
| IV | 50 mg | Daily for 7 days | 60 older people with heart failure[4] |
| Injection (under skin, muscle or IV push) | 100 mg | Single dose | Registered trial, no results[5] |
| Oral NR | 100, 300 or 1,000 mg | Daily for 8 weeks | Healthy overweight adults[8] |
| Oral NR | 1,000 mg twice daily | 12 weeks | Obese men[9] |
| Oral NR | 500 mg twice daily | 52 weeks | Early Parkinson’s disease[10] |
| Oral NMN | 250 mg | Daily for 10 weeks | Women with prediabetes[11] |
| Oral NMN | 300, 600 or 900 mg | Daily for 60 days | Healthy middle-aged adults[12] |
IV NAD+ doses
The 750 mg, 6-hour infusion
In a 2019 pilot, 8 healthy men received 750 mg of NAD+ by IV over 6 hours, a rate of about 2 mg a minute; 3 others received salt water.[1]
- Blood NAD+ did not change for the first 2 hours, because the body cleared it as fast as it went in.
- After that, levels climbed to about 400% above baseline by the end of the infusion.
- No adverse events were observed during the slow infusion.
The 500 mg clinic infusions
A 2026 review of wellness-clinic records looked at people given 500 mg of IV NAD+ on 4 days in a row.[2] They reported moderate to severe stomach symptoms, a faster heart rate and chest pressure during infusions, which ended when the infusion stopped. Because of these symptoms, the infusions took an average of 97 minutes. The authors worked for the clinic chain.
Low-dose hospital trials
Two Chinese heart failure trials used far smaller amounts alongside standard heart drugs:
- 10 mg a day for 7 days in 180 people: heart pumping (ejection fraction) was modestly better at 1 month than with placebo (45.4% vs 42.4%).[3]
- 50 mg a day for 7 days in 60 older people: improvements were not statistically significant.[4]
These were short courses for a specific heart condition, not wellness dosing.
NAD+ injection dosage and frequency
Shots of NAD+ under the skin or into a muscle are widely offered, but they are the least studied form.
- One registered trial compares 100 mg of NAD+ with 100 mg of nicotinamide riboside, given under the skin, into a muscle or by IV push, against placebo. It was listed as recruiting, with an estimated completion in mid-2025, and no results have been posted.[5]
- No published frequency. No study has tested a repeated schedule such as daily, twice weekly or weekly shots.
- No outcome trials. A 2026 systematic review of 33 human studies found no trials of IV or injected NAD+ itself for anti-aging or wellness outcomes.[6]
A 2026 narrative review concluded that the optimal dose of IV NAD+ cannot currently be established.[7] For the evidence and side effects of shots in more detail, see our NAD+ injection guide.
Oral NMN and NR doses
NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are building blocks the body turns into NAD+. They have far more human dose data than NAD+ itself.
- NR raises blood NAD+ in a dose-dependent way. In an 8-week trial, 100, 300 and 1,000 mg a day raised whole-blood NAD+ by 22%, 51% and 142% within 2 weeks, with no difference in adverse events from placebo.[8]
- Higher NR doses were tolerated but did not help metabolism. 2,000 mg a day for 12 weeks caused no serious adverse events in obese men, but did not improve insulin sensitivity.[9]
- The longest trial was negative. In NOPARK, 500 mg of NR twice daily for a year left people with early Parkinson’s disease slightly worse than placebo.[10]
- NMN doses ranged from 250 to 2,000 mg a day across 15 trials lasting 14 days to 24 weeks. NMN did not increase adverse events, but it also did not change weight, blood sugar or cholesterol.[13]
- More was not always better. In the 300 to 900 mg NMN trial, blood NAD+ was highest on 600 and 900 mg.[12]
How long oral doses take
In a 2026 study of 1,200 mg a day of NR or NMN, blood NAD+ rose slowly and leveled off after about two weeks. Brain NAD+ rose measurably after four weeks, and once-daily dosing kept levels stable. Responses varied a lot between people.[14]
For a fuller comparison of pills and shots, see our guide to NAD+ supplements vs injections.
Why no approved dose exists
- Not an approved drug. NAD+ has no FDA-approved label for any condition. FDA lists NAD among bulk substances still under evaluation for use by compounding pharmacies.[15]
- Few dose-finding studies. IV and injected NAD+ have not been tested across a range of doses for any health outcome.[6][7]
- Blood levels are not outcomes. Every form raises NAD+ in the blood, but a 2026 review found that effects on function, metabolism and other health measures were mixed and often null.[6]
For converting milligrams on a vial into syringe units, see our peptide calculator and our guide on how to calculate peptide dosage. They do the math; they do not choose a dose.
Questions to ask a clinician
- Which study is this NAD+ dose based on, and was it tested for my goal?
- How fast will an infusion run, and what happens if I feel chest pressure or nausea?
- How often will I get it, and why that schedule?
- Is the product pharmaceutical grade and tested for sterility?
- Would an oral precursor, which has more safety data, be a reasonable alternative?
Some people try other routes; see NAD+ nasal spray for what is known about that option. Talk to a licensed clinician before starting any NAD+ product.
